Ethnic differences in creatinine kinetics in a New Zealand end-stage kidney disease cohort

Autor:	Tina Y-T, Sun, Katie E, Lee, Jamie C, Kendrick-Jones, Mark R, Marshall
Rok vydání:	2013
Předmět:	Male Native Hawaiian or Other Pacific Islander Body Weight Middle Aged Models Biological White People Body Mass Index Kinetics Asian People Predictive Value of Tests Creatinine Humans Kidney Failure Chronic Female Peritoneal Dialysis Biomarkers Aged Glomerular Filtration Rate New Zealand Retrospective Studies
Zdroj:	Nephrology (Carlton, Vic.). 18(3)
ISSN:	1440-1797
Popis:	Recent data have suggested that glomerular filtration rate (GFR) is better predicted in New Zealand (NZ) Māori and Pacific People using the equations for Black people that predict higher GFR for any given serum creatinine. We hypothesized that this might be due to a higher rate of creatinine generation in NZ Māori and Pacific People.To compare creatinine kinetics between different ethnic groups in a cohort of NZ peritoneal dialysis patients.In this retrospective single-centre observational study, creatinine kinetics in 181 patients were determined from timed serum samples, peritoneal dialysate and urine collections between 1 October 2004 and 31 July 2011. Ethnicity was classified as Asian, NZ European, NZ Māori and Pacific People.A total of 799 samples from 181 patients were analysed: 194 in Asians, 127 in NZ Europeans, 268 in NZ Māori, 207 in Pacific People. Pacific People had the highest serum creatinine and lean body mass, and the highest creatinine generation rate at 1349 mg/day, compared with 1049 for Asians, 1186 for NZ Europeans and 1094 for NZ Māori (P = 0.0001). After adjustment for confounding factors, Pacific People had a greater creatinine generation by 140 mg/day compared with NZ Europeans (P = 0.047).Pacific People on peritoneal dialysis in NZ have higher serum creatinine, lean body mass and creatinine generation than other ethnic groups. This is consistent with previous observations that equations for predicting GFR in Black people may have increased accuracy in some Australasian non-White non-Asian populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::46f89e8330fb8dc3bdfdbe1bbbc66d08 https://pubmed.ncbi.nlm.nih.gov/23331989 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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