Immunologic localization of alpha- and beta-endorphins and beta-lipotropin in corticotropic cells of the normal and anencephalic fetal pituitaries

Autor:	M, Bégeot, M P, Dubois, P M, Dubois
Rok vydání:	1978
Předmět:	Male beta-Lipotropin Anencephaly Adrenocorticotropic Hormone Pituitary Gland Anterior Pituitary Gland Fluorescent Antibody Technique Humans Female Gestational Age Endorphins
Zdroj:	Cell and tissue research. 193(3)
ISSN:	0302-766X
Popis:	The use of antibodies to alpha-(17--39) ACTH, beta-LPH, and alpha- and beta-endorphins has enabled the detection of immunoreactive cells as early as the eight week of fetal life. Immunoreactive cells are located in the anterior and intermediate lobes of the pituitary gland in normal human fetuses. The same cells reacted with different antisera used in the present study. No immunoreactive cells were observed in the posterior lobe. The specificity of the immunocytological reaction has been controlled. In seven anencephalic fetuses, the presence of immunoreactive cells suggests that ACTH and beta-LPH can originate from a common precursor and are synthesized independent of the hypothalamus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::46f21eae2f2d4b3d0120c87fce6a26a8 https://pubmed.ncbi.nlm.nih.gov/215310 Zobrazit plný text záznamu Full text from SpringerLink