Autor:	J F, Loring
Rok vydání:	2011
Zdroj:	Methods in molecular medicine. 32
ISSN:	1543-1894
Popis:	Amyloid precursor protein (APP) and Alzheimer's disease are irrevocably linked, as APP is cleaved to form the Aβ peptides that are the major components of amyloid plaques. One of the most resilient hypotheses about the cause of AD centers on the Aβ peptide; all genetic causes and risk factors can be fitted into a general "amyloid cascade hypothesis," which maintains that all pathology is initiated by an abnormal accumulation of Aβ amyloid (1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::46b9c454c46e873d2e1d288175d76d3f https://pubmed.ncbi.nlm.nih.gov/21318524 Zobrazit plný text záznamu