| Popis: |
Axons in the brain and peripheral nervous system are enveloped by myelin sheaths, which are composed of stacked membrane bilayers containing large fractions of cholesterol, phospholipids, and glycolipids. The oxygen availability to the nearby oxygen consuming cytochrome c oxidase in the mitochondria is essential for the well-functioning of a cell. By constructing a rate network model based on molecular dynamics simulations, and solving it for steady-state conditions, this work calculates the oxygen storage in stacked membranes under an oxygen gradient. It is found that stacking membranes increases the oxygen storage capacity, indicating that myelin can function as an oxygen reservoir. However, it is found that the storage enhancement levels out for stacks with a large number of bilayers, suggesting why myelin sheaths consist of only 10-300 membranes rather than thousands. The presence of additional water between the stacked bilayers, as seen in cancer cells, is shown to diminish myelin oxygen storage enhancement. |
