Assessment of extracellular field potential and Ca

Autor:	Najah, Abi-Gerges, Amy, Pointon, Karen L, Oldman, Martin R, Brown, Mark A, Pilling, Clare E, Sefton, Helen, Garside, Christopher E, Pollard
Rok vydání:	2016
Předmět:	Drug-Related Side Effects and Adverse Reactions Induced Pluripotent Stem Cells Cell Culture Techniques Drug Evaluation Preclinical Action Potentials Cardiotoxicity Culture Media Long QT Syndrome Pharmaceutical Preparations Humans Myocytes Cardiac Calcium Channels Microelectrodes Cells Cultured
Zdroj:	Journal of pharmacological and toxicological methods. 83
ISSN:	1873-488X
Popis:	Cardiovascular toxicity is a prominent reason for failures in drug development, resulting in the demand for assays that can predict this liability in early drug discovery. We investigated whether iCell® cardiomyocytes have utility as an early QT/TdP screen. Thirty clinical drugs with known QT/TdP outcomes were evaluated blind using label-free microelectrode array (parameters measured were beating period (BP), field potential duration (FPD), fast Na
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4676831fce625efd0420851e06beea68 https://pubmed.ncbi.nlm.nih.gov/27622857 Zobrazit plný text záznamu Full Text from ScienceDirect