In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

Autor:	K, Kang, K-S, Wong, C Jayampath, Seneviratne, L P, Samaranayake, W-P, Fong, P W-K, Tsang
Rok vydání:	2009
Předmět:	Fungal Proteins Antifungal Agents Microbial Viability Phospholipases Amphotericin B Metergoline Drug Synergism Microbial Sensitivity Tests Candida
Zdroj:	Mycoses. 53(6)
ISSN:	1439-0507
Popis:	Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml(-1) respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4645a4a9854030d7dabbceeda1a9f24c https://pubmed.ncbi.nlm.nih.gov/19538518 Zobrazit plný text záznamu Plný text