| Autor: |
Sarah, Ghonim, Michael A, Gatzoulis, Sabine, Ernst, Wei, Li, James C, Moon, Gillian C, Smith, Ee Ling, Heng, Jennifer, Keegan, Siew Yen, Ho, Karen P, McCarthy, Darryl F, Shore, Anselm, Uebing, Aleksander, Kempny, Francisco, Alpendurada, Gerhard P, Diller, Konstantinos, Dimopoulos, Dudley J, Pennell, Sonya V, Babu-Narayan |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
JACC. Cardiovascular imaging. 15(2) |
| ISSN: |
1876-7591 |
| Popis: |
This study sought to identify patients with repaired tetralogy of Fallot (rTOF) at high risk of death and malignant ventricular arrhythmia (VA).To date there is no robust risk stratification scheme to predict outcomes in adults with rTOF.Consecutive patients were prospectively recruited for late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) to define right and left ventricular (RV, LV) fibrosis in addition to proven risk markers.The primary endpoint was all-cause mortality. Of the 550 patients (median age 32 years, 56% male), 27 died (mean follow-up 6.4 ± 5.8; total 3,512 years). Mortality was independently predicted by RVLGE extent, presence of LVLGE, RV ejection fraction ≤47%, LV ejection fraction ≤55%, B-type natriuretic peptide ≥127 ng/L, peak exercise oxygen uptake (V0We present a score integrating multiple appropriately weighted risk factors to identify the subgroup of patients with rTOF who are at high annual risk of death who may benefit from targeted therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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