Shape analysis of the hippocampus in Alzheimer’s disease and subtypes of frontotemporal lobar degeneration
| Autor: | Lindberg, Olof, Walterfang, Mark, Looi, Jeffrey C.L., Malykhin, Nikolai, Östberg, Per, Zandbelt, Bram, Styner, Martin, Velakoulis, Dennis, Örndahl, Eva, Cavallin, Lena, Wahlund, Lars-Olof |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male CA2 Region Hippocampal nutritional and metabolic diseases Middle Aged CA3 Region Hippocampal Hippocampus Magnetic Resonance Imaging Article nervous system diseases nervous system Alzheimer Disease mental disorders Dentate Gyrus Humans Dementia Female Primary Progressive Nonfluent Aphasia Atrophy Frontotemporal Lobar Degeneration CA1 Region Hippocampal Aged |
| Popis: | Hippocampal pathology is central to Alzheimer's disease (AD) and other forms of dementia such as frontotemporal lobar degeneration (FTLD). Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in particular the subiculum and cornu ammonis 1 (CA1). We conducted shape analysis of hippocampi segmented from structural T1 MRI images on clinically diagnosed dementia patients and controls. The subjects included 19 AD and 35 FTLD patients [13 frontotemporal dementia (FTD), 13 semantic dementia (SD), and 9 progressive nonfluent aphasia (PNFA)] and 21 controls. Compared to controls, SD displayed severe atrophy of the whole left hippocampus. PNFA and FTD also displayed atrophy on the left side, restricted to the hippocampal head in FTD. Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. Consistent with neuropathological studies, most atrophic deformation was found in CA1 and subiculum areas in FTLD and AD. |
| Databáze: | OpenAIRE |
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