BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines
| Autor: | D M, Jaworski, G M, Kelly, J M, Piepmeier, S, Hockfield |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Adolescent Brain Neoplasms Nerve Tissue Proteins Glioma Middle Aged Neoplasm Proteins Rats Rats Sprague-Dawley Chondroitin Sulfate Proteoglycans Rats Inbred Lew Child Preschool Biomarkers Tumor Tumor Cells Cultured Animals Humans Female Lectins C-Type Neoplasm Invasiveness Hyaluronic Acid Carrier Proteins In Situ Hybridization Neoplasm Transplantation Brevican |
| Zdroj: | Cancer research. 56(10) |
| ISSN: | 0008-5472 |
| Popis: | Malignant gliomas aggressively invade the surrounding normal brain, whereas brain metastases of nonglial tumors do not. The invasive behavior of gliomas may be mediated by tissue- or tumor-specific extracellular proteins. mRNA for the brain-specific extracellular brain enriched hyaluronan-binding protein (BEHAB) is not detectable in normal adult human cortex or in any nonglioma tumor examined. BEHAB is consistently expressed in surgical samples of glioma (n = 27). Glioma cell lines maintained under standard cell culture conditions or grown as s.c. tumors do not express BEHAB. When grown as intracranial grafts, glioma cell lines that invade the brain express BEHAB, whereas noninvasive cell lines do not. BEHAB is a unique and selective marker for glioma and may play a role in tumor invasion. |
| Databáze: | OpenAIRE |
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