Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens
| Autor: | S, Malarkannan, T, Horng, P, Eden, F, Gonzalez, P, Shih, N, Brouwenstijn, H, Klinge, G, Christianson, D, Roopenian, N, Shastri |
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| Rok vydání: | 2000 |
| Předmět: |
Cytotoxicity
Immunologic Antigen Presentation Mice Inbred BALB C Minor Histocompatibility Loci Base Sequence Transcription Genetic Molecular Sequence Data H-2 Antigens Antigen-Presenting Cells Epitopes T-Lymphocyte Lymphocyte Activation Cell Line Mice Inbred C57BL Minor Histocompatibility Antigens Mice Animals Amino Acid Sequence Oligopeptides Protein Binding T-Lymphocytes Cytotoxic |
| Zdroj: | Immunity. 13(3) |
| ISSN: | 1074-7613 |
| Popis: | Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells. |
| Databáze: | OpenAIRE |
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