| Autor: |
P, Coudert, E, Duroux, P, Bastide, J, Couquelet, P, Tronche |
| Jazyk: |
francouzština |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Journal de pharmacie de Belgique. 46(6) |
| ISSN: |
0047-2166 |
| Popis: |
It has been possible to prepare from 4,6-diaryl pyridazinones a series of derivatives substituted in the 2-position by chains of various lengths bearing a carboxylic acid function. Pig lens aldose reductase inhibitory activity was evaluated for all compounds. N-acetic acid derivative 3c with a chlorine atom on the phenyl nucleus at the 6-position on the pyridazin ring was the most active pyridazinone with an IC50 value of 1.2 x 10(-5) M. Furthermore, it has been shown that lipophilicity and spatial configuration of the synthesized compounds took a prominent part on enzymatic activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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