Valproic Acid Inhibits Human Retinal Pigment Epithelial (hRPE) Cell Proliferation Via a P38 MAPK Signaling Mechanism

Autor:	Rohit, Anand, Piyush C, Kothary, Monte A, Del Monte
Rok vydání:	2018
Předmět:	Cell Nucleus Dose-Response Relationship Drug MAP Kinase Signaling System Enzyme Induction Valproic Acid Drug Evaluation Preclinical Humans Retinal Pigment Epithelium p38 Mitogen-Activated Protein Kinases Cells Cultured Cell Proliferation
Zdroj:	Advances in experimental medicine and biology. 1074
ISSN:	0065-2598
Popis:	Valproic acid (VPA) has been reported to inhibit cancer cell growth and has therapeutic use in retinal diseases. However, the mechanism of this action remains unclear. In order to explore this mechanism, primary human retinal pigment epithelial (hRPE) cell cultures were established. Cell viability was assessed by the trypan blue exclusion method (T), and the cell proliferation was measured by
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::458c5dd179096e00a40a0c8552dce540 https://pubmed.ncbi.nlm.nih.gov/29721975 Zobrazit plný text záznamu