[Coronary artery stenting without antivitamin K. Results after a month]
| Autor: | G, Zemour, M C, Morice, E, Benveniste, Y, Biron, Y, Lienhart, B, Valeix, Y, Louvard, B, Glatt, T, Lefevre, Y, Guérin |
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| Jazyk: | francouzština |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Aged 80 and over Male Ticlopidine Aspirin Anticoagulants Coronary Disease Thrombosis Heparin Low-Molecular-Weight Middle Aged Treatment Outcome Humans Drug Therapy Combination Female Stents Thrombolytic Therapy Angioplasty Balloon Coronary Platelet Aggregation Inhibitors Aged Follow-Up Studies |
| Zdroj: | Archives des maladies du coeur et des vaisseaux. 89(3) |
| ISSN: | 0003-9683 |
| Popis: | This paper reports experience with a new antithrombotic agent prescribed to reduce the incidence of subacute occlusions during the first month after coronary stenting. Therefore, a powerful association of platelet antiaggregant agents was tested. From December 1992 to October 1994, coronary stenting was successfully achieved in 1,294 patients (1,118 men, average age 60.5 +/- 10 years) who were then treated with the association of ticlopidine 0.25 g/day and aspirin 0.10 g/day for one month. This was covered with anticoagulation with a low molecular weight heparin for a variable period (one month, two weeks, then one week), according to the different phases of the study protocol. In all, 1487 stents were successfully implanted (1,330 Palmaz Schatz; 63 Cook; 80 Wictor; 13 AVE and 1 Strecker) in 1,326 vessels (520 left anterior descending, 208 left circumflex, 475 right coronary, 16 left main coronary arteries and 107 venous grafts) using balloon catheters of 2.5 mm to 5 mm diameter for average 3.45 +/- 0.4 mm). Major complications in the first month included 9 deaths (0.7%), 22 occlusions (1.7%): 14 myocardial infarcts (1%) and 11 aorto-coronary bypass procedures (0.85%). There were 136 local haematomas or false aneurysms (10.5%), 42 of which (3.25%) required blood transfusion or surgical repair. This multicenter trial of a protocol associating platelet antiaggregant agents and low molecular weight heparin for one month showed a low incidence of subocclusion after coronary stenting (1.7 +/= 2.5%) and should enable interventional cardiologists to widen the indications for coronary stenting. |
| Databáze: | OpenAIRE |
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