Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1
| Autor: | John D, Lee, Tanya S, McDonald, Jenny N T, Fung, Trent M, Woodruff |
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| Rok vydání: | 2020 |
| Předmět: |
Receptor for Advanced Glycation End Products
Mice Transgenic Severity of Illness Index Superoxide Dismutase-1 Animals RNA Messenger Inflammation Hand Strength Macrophages Muscles Amyotrophic Lateral Sclerosis Denervation Survival Analysis Hindlimb Up-Regulation DNA-Binding Proteins Mice Inbred C57BL Disease Models Animal Spinal Cord Astrocytes Rotarod Performance Test Disease Progression Cytokines Microglia Biomarkers Gene Deletion |
| Zdroj: | Molecular neurobiology. 57(10) |
| ISSN: | 1559-1182 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron degenerative disease that is without effective treatment. The receptor for advanced glycation end products (RAGE) is a major component of the innate immune system that has been implicated in ALS pathogenesis. However, the contribution of RAGE signalling to the neuroinflammation that underlies ALS neurodegeneration remains unknown. The present study therefore generated SOD1 |
| Databáze: | OpenAIRE |
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