| Autor: |
D, Valmori, V, Dutoit, V, Rubio-Godoy, C, Chambaz, D, Liénard, P, Guillaume, P, Romero, J C, Cerottini, D, Rimoldi |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Cancer research. 61(2) |
| ISSN: |
0008-5472 |
| Popis: |
MAGE genes encode tumor-specific shared antigens that are among the most interesting candidates for cancer vaccines. Despite extensive studies, however, CD8+ T-cell responses to MAGE-derived epitopes have been detected only occasionally in cancer patients, even after vaccination. In contrast with these findings, we report here that HLA-A2 melanoma patients respond frequently to the recently identified peptide MAGE-A10(254-262). Indeed, as assessed by staining with fluorescent HLA-A2/peptide MAGE-A10(254-262) tetramers, CD8+ T cells directed against this peptide were readily detectable in a large proportion of HLA-A2+ melanoma patients. These results provide new insight into the immunogenicity of MAGE antigens and underline the potential usefulness of MAGE-A10 peptide-based cancer vaccines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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