| Autor: |
Sayyad, Ali, Muhammad Hassham, Hassan Bin Asad, Muhammad Arslan, Javed, Tariq, Javed, Yasser Msa, Al-Kharaman, Muhammad, Latif, Sabeeh, Mohsin, Taufiq, Nawaz, Syed Muhammad, Farid Hasan, Jamshed, Iqbal, Borhan, Babak, Izhar, Hussain |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Pakistan journal of pharmaceutical sciences. 35(5) |
| ISSN: |
1011-601X |
| Popis: |
BACE1 enzyme has been known a potential target involved in Alzheimer's disease (AD). Present research was focused on the principles of virtually screening, chemical synthesis and protease inhibitory effect of BACE1 enzyme via biaryl guanidine derivatives. In-silico based paradigm (ligand binding interaction within active domain of BACE 1 enzyme i.e., aspartate Asp32 and Asp228) a novel compound was synthesized and subsequently subjected to in-vitro and in-vivo evaluation. 1,3-di(isoquinolin-6-yl) guanidine was synthesized and found potent (IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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