| Autor: |
Xiaoli, Wang, Li, Zhang, Rong-qing, Ou, Jing, Wang, Shu-yun, Liu, Qiang, Chen, Pin-can, Su |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 25(1) |
| ISSN: |
1003-9406 |
| Popis: |
To study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.MspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.There was no significant correlation between MspI polymorphism and ICP susceptibility (P0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).The Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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