| Autor: |
Severien, Meyers, Marleen, Lox, Sirima, Kraisin, Laurens, Liesenborghs, Caroline P, Martens, Liesbeth, Frederix, Stijn, Van Bruggen, Marilena, Crescente, Dominique, Missiakas, Pieter, Baatsen, Thomas, Vanassche, Peter, Verhamme, Kimberly, Martinod |
| Rok vydání: |
2022 |
| Zdroj: |
Arteriosclerosis, thrombosis, and vascular biology. |
| ISSN: |
1524-4636 |
| Popis: |
Infective endocarditis (IE) is characterized by an infected thrombus at the heart valves. How bacteria bypass the immune system and cause these thrombi remains unclear. Neutrophils releasing NETs (neutrophil extracellular traps) lie at this interface between host defense and coagulation. We aimed to determine the role of NETs in IE immunothrombosis.We used a murine model ofNeutrophils releasing NETs were present in infected thrombi and within cellular infiltrates in the surrounding vasculature. Neutrophil depletion increased occurrence of IE, whereas neutrophil-selective impairment of NET formation did not alter IE occurrence. Absence ofNeutrophils protect against IE independent of NET release. Absence of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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