| Autor: |
Carolina Assis P, Vilela, Andre, Messias, Rodrigo T, Calado, Rubens C, Siqueira, Marcelo Jordão L, Silva, Dimas T, Covas, Jayter S, Paula |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Documenta ophthalmologica. Advances in ophthalmology. 143(1) |
| ISSN: |
1573-2622 |
| Popis: |
To report electroretinographic (ERG) findings in advanced glaucoma treated with a single intravitreal injection of bone marrow-derived mesenchymal stem cells (MSCs).Intravitreal injection of autologous MSCs (1 × 10Patients did not show improvement on visual acuity or visual field after treatment. At baseline, ERG responses showed typical findings for advanced glaucoma, with a- and b-wave amplitude and latency within normative range, but reduced photopic negative responses. No noteworthy changes were observed on ERG responses for both cases up to 1 week after treatment, but at day 15, one patient showed retinal detachment with proliferative vitreoretinopathy and was removed from the trial. The other patient kept ERG responses stable throughout study period.Although no ERG response changes were observed after MSCs injection in one case, the complication observed on the second one, along with the lack of visual function improvement, warrants further studies involving modified MSCs to treat ocular disorders, including glaucoma.ClinicalTrials.gov, NCT02330978- missed in pdf. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink