Rational Development of Stable PYY

Autor: Christian, Poulsen, Marie Østergaard, Pedersen, Per-Olof, Wahlund, Annika, Sjölander, Jens Kaalby, Thomsen, Kilian W, Conde-Frieboes, Johan F, Paulsson, Birgitte S, Wulff, Søren, Østergaard
Rok vydání: 2021
Předmět:
Zdroj: Pharmaceutical research. 38(8)
ISSN: 1573-904X
Popis: The anorectic effect of PYYHalf-life extended PYYDeamidation of asparagine in position 18 and 29 was observed upon incubation at 37°C. Asparagine in position 18 - but not position 29 - could be substituted to glutamine without detrimental effects on YBy rational design, a chemically and physically stable Y
Databáze: OpenAIRE