Autor: |
Laura, DeCristofano, Steven, Decker, Marvin K, Schulte, Asha, Suryanarayanan |
Rok vydání: |
2020 |
Předmět: |
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Zdroj: |
Alcohol (Fayetteville, N.Y.). 93 |
ISSN: |
1873-6823 |
Popis: |
Binge drinking can increase an individual's risk of developing alcohol use disorder (AUD). Ethanol targets multiple neurotransmitter systems; however, not much is known about its effects on the cholinergic system. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels, the heteromeric αEthanol-induced loss of righting reflex (LORR) duration was measured in the presence and absence of dFBr. The βPretreatment with 6 mg/kg dFBr reduced ethanol-induced LORR duration as compared to rats treated with ethanol alone. LORR studies with DHβE suggest that dFBr reduced ethanol-induced LORR duration via the βOur results suggest that thalamic nAChRs containing the α |
Databáze: |
OpenAIRE |
Externí odkaz: |
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