Desformylflustrabromine (dFBr), a positive allosteric modulator of the α

Autor:	Laura, DeCristofano, Steven, Decker, Marvin K, Schulte, Asha, Suryanarayanan
Rok vydání:	2020
Předmět:	Ethanol Animals Hypnotics and Sedatives Receptors Nicotinic Hydrocarbons Brominated Indole Alkaloids Rats
Zdroj:	Alcohol (Fayetteville, N.Y.). 93
ISSN:	1873-6823
Popis:	Binge drinking can increase an individual's risk of developing alcohol use disorder (AUD). Ethanol targets multiple neurotransmitter systems; however, not much is known about its effects on the cholinergic system. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels, the heteromeric αEthanol-induced loss of righting reflex (LORR) duration was measured in the presence and absence of dFBr. The βPretreatment with 6 mg/kg dFBr reduced ethanol-induced LORR duration as compared to rats treated with ethanol alone. LORR studies with DHβE suggest that dFBr reduced ethanol-induced LORR duration via the βOur results suggest that thalamic nAChRs containing the α
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::44af13f6463cc8aa778110501b1072ab https://pubmed.ncbi.nlm.nih.gov/33652092 Zobrazit plný text záznamu Full Text from ScienceDirect