| Autor: |
Chrysanthi, Voutyraki, Alexandros, Choromidis, Vasiliki, Theodorou, Christina, Efraimoglou, Gerasimos, Anagnostopoulos, Srivathsa S, Magadi, Sofia, Grammenoudi, Evanthia, Zacharioudaki, Christos, Delidakis |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
The International journal of developmental biology. 66(1-2-3) |
| ISSN: |
1696-3547 |
| Popis: |
Neural stem cells (NSC) in divide asymmetrically to generate one cell that retains stem cell identity and another that is routed to differentiation. Prolonged mitotic activity of the NSCs gives rise to the plethora of neurons and glial cells that wire the brain and nerve cord. Genetic insults, such as excess of Notch signaling, perturb the normal NSC proliferation programs and trigger the formation of NSC hyperplasias, which can subsequently progress to malignancies. Hes proteins are crucial mediators of Notch signaling, and in the NSC context they act by repressing a cohort of early pro-differentiation transcription factors. Downregulation of these pro-differentiation factors makes NSC progeny cells susceptible to adopting an aberrant stem cell program. We have recently shown thatWe have combined genetic analysis, tissue allografting and transcriptomic approaches to address the role ofWe show that theThe combination of dedifferentiation and cell physiology changes most likely drive tumour growth. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
