The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD

Autor:	Iori, Okura, Nanae, Hasuoka, Kanaho, Senoo, Akiko, Suganami, Keijo, Fukushima, John W, Regan, Masato, Mashimo, Toshihiko, Murayama, Yutaka, Tamura, Hiromichi, Fujino
Rok vydání:	2020
Předmět:	HEK293 Cells Prostaglandin D2 Receptors Prostaglandin Cyclic AMP Humans Receptors Immunologic Receptors Prostaglandin E EP2 Subtype Ligands Dinoprostone Adenylyl Cyclases Cell Line Cyclic Nucleotide Phosphodiesterases Type 4 Signal Transduction
Zdroj:	Pharmacological reports : PR. 73(3)
ISSN:	2299-5684
Popis:	Human DP and EP2 receptors are two of the most homologically related receptors coupling with GFirst, we focused on the cAMP degradation pathways of DP and EP2 receptors stimulated by prostaglandin (PG) DWe found that PGDSince DP receptors and EP2 receptors are considered to be duplicated genes, DP receptors may still be in a rapid evolutionary stage as a duplicated copy of EP2 receptors and have not yet sufficient selectivity for their cognate ligand, PGD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::448331de8f0656c40c72369c3feeb834 https://pubmed.ncbi.nlm.nih.gov/33786738 Zobrazit plný text záznamu Full text from SpringerLink