C4-dicarboxylates and l-aspartate utilization by Escherichia coli K-12 in the mouse intestine: l-aspartate as a major substrate for fumarate respiration and as a nitrogen source
| Autor: | Christopher, Schubert, Maria, Winter, Andrea, Ebert-Jung, Sylwia, Kierszniowska, Kerstin, Nagel-Wolfrum, Thorben, Schramm, Hannes, Link, Sebastian, Winter, Gottfried, Unden |
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| Rok vydání: | 2021 |
| Předmět: |
Dicarboxylic Acid Transporters
Aspartic Acid endocrine system diseases Escherichia coli K12 Nitrogen Escherichia coli Proteins Respiration nutritional and metabolic diseases Gene Expression Regulation Bacterial Article DNA-Binding Proteins Intestines Mice Fumarates Escherichia coli Animals Dicarboxylic Acids Protein Kinases hormones hormone substitutes and hormone antagonists Transcription Factors |
| Zdroj: | Environ Microbiol |
| ISSN: | 1462-2920 |
| Popis: | Fumarate was previously known to serve as an anaerobic electron acceptor by E. coli when colonizing the mammalian intestine, but the source of that fumarate was elusive. In this issue, Unden and coworkers demonstrate that l-aspartic acid is the source of fumarate that drives anaerobic respiration by colonized E. coli (Schubert et al., 2021). Moreover, Schubert et al., establish that E. coli is able to grow anaerobically by using aspartate as a sole source of nitrogen. These groundbreaking findings indicate that a single amino acid – aspartate – supports anaerobic respiration and acquisition of nitrogen by E. coli in the intestine. |
| Databáze: | OpenAIRE |
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