| Autor: |
Sandeepraj, Pusalkar, Xiaofei, Zhou, Yuexian, Li, Lawrence, Cohen, Jun Johnny, Yang, Suresh K, Balani, Cindy, Xia, Wen Chyi, Shyu, Chuang, Lu, Karthik, Venkatakrishnan, Swapan K, Chowdhury |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 48(3) |
| ISSN: |
1521-009X |
| Popis: |
Alisertib (MLN8237) is an investigational, orally available, selective aurora A kinase inhibitor in clinical development for the treatment of solid tumors and hematologic malignancies. This metabolic profiling analysis was conducted as part of a broader phase 1 study evaluating mass balance, pharmacokinetics, metabolism, and routes of excretion of alisertib following a single 35-mg dose of [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
