| Autor: |
Shaft Corrêa, Pinto, Gilda Guimarães, Leitão, Danilo Ribeiro, de Oliveira, Humberto Ribeiro, Bizzo, Daniela Fernandes, Ramos, Tatiane Silveira, Coelho, Pedro Eduardo A, Silva, Maria Cristina S, Lourenço, Suzana Guimarães, Leitão |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Natural product communications. 4(12) |
| ISSN: |
1934-578X |
| Popis: |
The essential oil from Anemia tomentosa var. anthriscifolia showed in vitro activity against Mycobacterium tuberculosis (MIC 100 microg/ml) and therefore was characterized by gas chromatography (GC) and by gas chromatography coupled with mass spectrometry (GC-MS). The major constituents of this essential oil were triquinane sesquiterpenes: silphiperfol-6-ene (14.7%), (-)-epi-presilphiperfolan-1-ol (30.6%), presilphiperfol-7-ene (3.9%), cameroonan-7 alpha-ol (4.4%), prenopsan-8-ol (1.9%) and presilphiperfolan-8-ol (8.3%), suggesting the existence of different chemotypes for this species. The essential oil was fractionated by column chromatography and its major constituent and fractions were assayed against Mycobacterium tuberculosis and M. smegmatis. (-)-epi-Presilphiperfolan-1-ol exhibited an MIC of 120 microg/ml against M. tuberculosis H37Rv. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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