| Autor: |
Rosa B, Thorolfsdottir, Gardar, Sveinbjornsson, Patrick, Sulem, Jonas B, Nielsen, Stefan, Jonsson, Gisli H, Halldorsson, Pall, Melsted, Erna V, Ivarsdottir, Olafur B, Davidsson, Ragnar P, Kristjansson, Gudmar, Thorleifsson, Anna, Helgadottir, Solveig, Gretarsdottir, Gudmundur, Norddahl, Sridharan, Rajamani, Bjarni, Torfason, Atli S, Valgardsson, Jon T, Sverrisson, Vinicius, Tragante, Oddgeir L, Holmen, Folkert W, Asselbergs, Dan M, Roden, Dawood, Darbar, Terje R, Pedersen, Marc S, Sabatine, Cristen J, Willer, Maja-Lisa, Løchen, Bjarni V, Halldorsson, Ingileif, Jonsdottir, Kristian, Hveem, David O, Arnar, Unnur, Thorsteinsdottir, Daniel F, Gudbjartsson, Hilma, Holm, Kari, Stefansson |
| Rok vydání: |
2018 |
| Zdroj: |
Communications biology. 1 |
| ISSN: |
2399-3642 |
| Popis: |
Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding variants associated with risk through unknown mechanisms. We performed a meta-analysis of GWAS of atrial fibrillation among 29,502 cases and 767,760 controls from Iceland and the UK Biobank with follow-up in samples from Norway and the US, focusing on low-frequency coding and splice variants aiming to identify causal genes. We observe associations with one missense (OR = 1.20) and one splice-donor variant (OR = 1.50) in |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
