[System of ethanol and acetaldehyde metabolism in the rat liver during the development of ethanol tolerance]

Autor:	V I, Satanovskaia
Rok vydání:	1990
Předmět:	Male Ethanol Liver Alcohol Dehydrogenase Animals Acetaldehyde Drug Tolerance Aldehyde Dehydrogenase Sleep Injections Intraperitoneal Rats
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 109(2)
ISSN:	0365-9615
Popis:	Following daily intraperitoneal injections of ethanol at a dose of 3.5 g/kg rats developed tolerance to its hypnotic action, which was manifested in a drastic decrease of ethanol--induced sleep time and the number of animals sleeping more than 60 min. In the liver, this process was characterized by an elevated alcohol dehydrogenase activity and a decreased aldehyde dehydrogenase one, whereas that of MEOS remained unchanged.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::43f42fa2458941e869ac7739cc86847e https://pubmed.ncbi.nlm.nih.gov/2337652 Zobrazit plný text záznamu