| Autor: |
M A, Gorbunov, A V, Noskova, G A, El'shina, T A, Bektimirov, L I, Pavlova, L A, Aksenov, A A, Ivanov |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Voprosy virusologii. 45(1) |
| ISSN: |
0507-4088 |
| Popis: |
Controlled field clinical trials of Avaxim vaccine from hepatitis A (Pasteur-Merrier-Connot) were carried out in adults and children aged 3-14 years to evaluate its reactogenicity and antigenic properties. The vaccine was weakly reactogenic both in adults and children. A single injection of the vaccine resulted after 1 month in the production of anti-HAV antibodies in 77.4% initially seronegative adults and 94.5% children. In adults the mean geometrical titer of antibodies was 95 mIU/ml and in children 165 mIU/ml, which was 5-8 times higher than the protective titer. These data recommend Avaxim vaccine for practical public health. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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