| Autor: |
L K, Mondal, K P, Baidya, B, Bhattacharya, P R, Chatterjee, G, Bhaduri |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of the Indian Medical Association. 102(12) |
| ISSN: |
0019-5847 |
| Popis: |
It is now proved that diabetic micro-angiopathy is caused by ischaemia at the capillary bed of retina due to reduced capillary blood flow in long standing type-2 diabetes mellitus. Deranged metabolic process due to chronic hypoxia at the tissue level produces visual and vascular dysfunction. Brimonidine tartrate, an alpha-2 agonist which is commonly used in glaucoma to protect retinal ganglion cells from pressure related ischaemia induced cell apoptosis, is administered in very early stage of non-proliferative diabetic retinopathy to reduce ischaemia at the capillary bed of retina. Improved visual acuity and decreased micro-aneurysm formation, which indicate elimination of ischaemic stimulus at the tissue level, are seen in long standing type-2 diabetes mellitus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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