Absorption, distribution and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis

Autor:	Masakazu, Shibata, Yoshihiko, Shimokawa, Katsunori, Sasahara, Noriaki, Yoda, Hiroyuki, Sasabe, Mitsunari, Suzuki, Ken, Umehara
Rok vydání:	2016
Předmět:	Male Placenta Antitubercular Agents Rats Rats Sprague-Dawley Feces Milk Intestinal Absorption Liver Nitroimidazoles Pregnancy Animals Bile Tuberculosis Female Tissue Distribution Maternal-Fetal Exchange Oxazoles
Zdroj:	Biopharmaceuticsdrug disposition. 38(4)
ISSN:	1099-081X
Popis:	Delamanid (OPC-67683, Deltyba™, nitro-dihydro-imidazooxazoles derivative) is approved for the treatment of adult pulmonary multidrug-resistant tuberculosis. The absorption, distribution and excretion of delamanid-derived radioactivity were investigated after a single oral administration of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::43cc0f2590106d7ac9cbb6f88719f5b6 https://pubmed.ncbi.nlm.nih.gov/28092695 Zobrazit plný text záznamu Plný text