The potential of intranasal delivery of nanocrystals in powder form on the improvement of zaleplon performance

Autor:	Randa, Latif, Rana R, Makar, Ehab A, Hosni, Omaima N, El Gazayerly
Rok vydání:	2021
Předmět:	Pyrimidines Solubility Acetamides Administration Oral Animals Biological Availability Nanoparticles Rabbits Particle Size Powders
Zdroj:	Drug development and industrial pharmacy. 47(2)
ISSN:	1520-5762
Popis:	The present work focuses on improving zaleplon (ZAP) performance through nanosizing its insoluble particles which were then delivered intranasally in powder form.Since nanopowders have an exceptional ability to cross cell membrane, their absorption is facilitated in the solid form. Hence, delivering insoluble ZAP nanocrystals (NC) through intranasal route improves its bioavailability due to both nanosization and the escape of hepatic metabolism.Nanocrystals were prepared by anti-solvent precipitation followed by probe sonication in presence of SoluplusNanosization to 200 nm contributed to the enhancement in dissolution ∼100% within 30 min and reduced half-life to 1.63 min. Confirmation of adsorption of polymers over NC' surface was elucidated. TGA confirmed their thermal stability.The intranasal delivery of nanoscale ZAP powder proved to be a successful alternative to oral formulations that suffer poor absorption and limited bioavailability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::43a840978c0de1dde74b50fa8793a380 https://pubmed.ncbi.nlm.nih.gov/33501862 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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