[Comparative analysis of antiarrhythmic and proarrhythmogenic effects of drugs for neuroleptanalgesia, ataralgesia, and antidepranalgesia in experimental acute myocardial infarction]

Autor:	A M, Iakushev, M P, Iakushev, A V, Sapozhkov
Rok vydání:	2006
Předmět:	Diazepam Carbazoles Myocardial Infarction Neuroleptanalgesia Arrhythmias Cardiac Blood Pressure Promedol Myocardial Contraction Antidepressive Agents Analgesics Opioid Disease Models Animal Heart Rate Tachycardia Animals Hypnotics and Sedatives Rabbits Analgesia Anti-Arrhythmia Agents Tramadol
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 69(4)
ISSN:	0869-2092
Popis:	Proarrhythmogenic and antiarrhythmic effects of drugs for neuroleptanalgesia (NLA), ataralgesic (ATA) and antidepranalgesia (ADA) in chronic experiments on sleepless rabbits with acute myocardial infarction, with and without tachyarrhythmias, were studied using ECG, intraventricular electromanometry and tetropolar rheography. NLA (phentanylum, 1 microg/kg + droperidol, 5 microg/kg), ADA (pyrazidole, 1 mg/kg + tramal, 1 mg/kg) and ATA (diazepam, 1 mg/kg + promedol 0.5 mg/kg) produce antiarrhythmic effect with maximum manifestation of NLA on the 3rd day, and of ATA and ADA on 3-5th day. This medication increased blood supply and contractility of ischemic myocardium. Proarrhythmogenic effects of this medication were not observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::436d8fd06000790cc97dd57acd235a5c https://pubmed.ncbi.nlm.nih.gov/16995434 Zobrazit plný text záznamu