| Autor: |
D F, Chiuten, J M, Bennett, R H, Creech, J, Glick, G, Falkson, H S, Brodovsky, C B, Begg, F M, Muggia, P P, Carbone |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
Cancer treatment reports. 63(1) |
| ISSN: |
0361-5960 |
| Popis: |
Thirty-six patients with stage III and IV Hodgkin's disease and non-Hodgkin's lymphoma, who had become refractory to conventional chemotherapy, were treated with VM-26. Complete remissions were documented in two patients with diffuse histiocytic lymphoma. Six patients (four with non-Hodgkin's lymphomas and two with Hodgkin's disease) had partial remissions. The overall response rate was 22% (eight of 36 patients). Hematologic toxicity was the most frequent dose-limiting toxicity. Nonhematologic toxic effects were mild and acceptable. This study demonstrates that VM-26 can produce tumor responses in refractory lymphomas. The Eastern Cooperative Oncology Group is currently planning two new phase II studies to incorporate VM-26 with other active new agents, one involving hexamethylmelamine and the other involving cis-dichlorodiammineplatinum(II). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
