| Autor: |
Stephen J, Woolford, Stefania, D'Angelo, Giulia, Mancano, Elizabeth M, Curtis, Shanze, Ashai, Nitin, Shivappa, James R, Hébert, Sarah R, Crozier, Catherine M, Phillips, Matthew, Suderman, Caroline L, Relton, Cyrus, Cooper, Nicholas C, Harvey |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 37(8) |
| ISSN: |
1523-4681 |
| Popis: |
Systemic inflammation is associated with reduced bone mineral density and may be influenced by pro-inflammatory diets. We undertook an observational analysis of associations between late pregnancy energy-adjusted dietary inflammatory index (E-DII) scores and offspring bone outcomes in childhood. E-DII scores (higher scores indicating pro-inflammatory diets) were derived from food frequency questionnaires in late pregnancy in two prospective mother-offspring cohorts: the Southampton Women's Survey (SWS) and the Avon Longitudinal Study of Parents and Children (ALSPAC). The mean (SD) offspring age at dual-energy X-ray absorptiometry (DXA) scanning was 9.2 (0.2) years. Linear regression was used to assess associations between E-DII and bone outcomes, adjusting for offspring sex and age at DXA and maternal age at childbirth, educational level, pre-pregnancy body mass index (BMI), parity, physical activity level, and smoking in pregnancy. Associations were synthesized using fixed-effect meta-analysis. Beta coefficients represent the association per unit E-DII increment. In fully adjusted models (total n = 5910) late pregnancy E-DII was negatively associated with offspring whole body minus head bone area (BA: β = -3.68 [95% confidence interval -6.09, -1.27] cm |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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