Sexual dimorphism in prostacyclin-mimetic responses within rat mesenteric arteries: A novel role for K

Autor:	Samuel N, Baldwin, Elizabeth A, Forrester, Lauren, McEwan, Iain A, Greenwood
Rok vydání:	2021
Předmět:	Male Sex Characteristics KCNQ1 Potassium Channel Receptors Prostaglandin Animals Inositol 1 4 5-Trisphosphate Receptors Female Iloprost Rats Wistar Receptors Epoprostenol Epoprostenol Mesenteric Arteries Rats
Zdroj:	British journal of pharmacology. 179(7)
ISSN:	1476-5381
Popis:	Prostacyclin mimetics express potent vasoactive effects via prostanoid receptors that are not unequivocally defined, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of IP and EPWithin second-order mesenteric arteries from male and female Wistar rats, we determined (1) relative mRNA transcripts for EPIloprost evoked a biphasic response in male mesenteric arteries, at concentrations ≤100 nmol·LStark sexual dimorphisms in iloprost-mediated vasoactive responses are present within mesenteric arteries. K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::433737a346f992bc39fa11da367908ee https://pubmed.ncbi.nlm.nih.gov/34766649 Zobrazit plný text záznamu Plný text