Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves

Autor:	KOMATSU, Tetsuya, YOSHIDA, Erina, SHIGENAGA, Ayumi, YASUIE, Nozomi, UCHIYAMA, Shintaro, TAKAMURA, Yuji, SUGIE, Kennosuke, KIMURA, Kumiko, HARITANI, Makoto, SHIBAHARA, Tomoyuki
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Klebsiella pneumoniae cattle multidrug resistance Drug Resistance Multiple Bacterial RNA Ribosomal 16S Pathology Animals meningoencephalitis Cattle Diseases Microbial Sensitivity Tests Note Anti-Bacterial Agents Klebsiella Infections
Zdroj:	The Journal of Veterinary Medical Science
ISSN:	1347-7439 0916-7250
Popis:	One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene sequencing of the No. 1 isolate and bacterial extracts from formalin fixed paraffin embedded sections of No. 2 revealed that both samples were K. pneumoniae. The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin. Immunosuppression is a significant septicemic K. pneumoniae infection risk factor. Our study provides new aspects regarding K. pneumoniae infections in cattle, bacterial meningoencephalitis differentiation, and K. pneumoniae and bacterial meningoencephalitis treatments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::433037034fe48cf1fadcee92a423bc7b http://europepmc.org/articles/PMC8349807 Zobrazit plný text záznamu