| Autor: |
Marta, Martorell, Rosa M, López, Esteban, Ribera, Isabel, Ruiz, Cristina, Tural, Lluís, Puig, Josep, Monterde |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Enfermedades infecciosas y microbiologia clinica. 23(6) |
| ISSN: |
0213-005X |
| Popis: |
The aim of this study was to evaluate efavirenz and nevirapine plasma levels in HIV-infected hemophilic patients seen in two hospitals in Barcelona. Plasma levels of these drugs were determined by high-performance liquid chromatography (HPLC) at four-month intervals, together with viral load and CD4 cell count. Nineteen patients treated with efavirenz and 8 with nevirapine were included, and 68 efavirenz and 31 nevirapine determinations were performed. Mean study time was 12 months. Median efavirenz plasma concentration was 2.95 .g/ml (interval: 1.54-5.26 .g/ml) in patients with favorable virological response and 1.86 .g/ml (0.82-4.88 .g/ml) in patients with detectable viral load (p = 0.32). Nevirapine plasma concentrations were 4.41 .g/ml (3.50-6.72 .g/ml) and 3.12 .g/ml (2.44-3.80 .g/ml) respectively (p = 0.18). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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