Translating cancer 'omics' to improved outcomes

Autor: Emily A, Vucic, Kelsie L, Thu, Keith, Robison, Leszek A, Rybaczyk, Raj, Chari, Carlos E, Alvarez, Wan L, Lam
Rok vydání: 2012
Předmět:
Zdroj: Genome research. 22(2)
ISSN: 1549-5469
Popis: The genomics era has yielded great advances in the understanding of cancer biology. At the same time, the immense complexity of the cancer genome has been revealed, as well as a striking heterogeneity at the whole-genome (or omics) level that exists between even histologically similar tumors. The vast accrual and public availability of multi-omics databases with associated clinical annotation including tumor histology, patient response, and outcome are a rich resource that has the potential to lead to rapid translation of high-throughput omics to improved overall survival. We focus on the unique advantages of a multidimensional approach to genomic analysis in this new high-throughput omics age and discuss the implications of the changing cancer demographic to translational omics research.
Databáze: OpenAIRE