Activated protein C and inflammation in human myocardium after heart surgery

Autor:	J, Petäjä, E, Pesonen, J A, Fernández, J H, Griffin, H, Repo, S E, Jansson, A E, Vento, O J, Rämö
Rok vydání:	2001
Předmět:	Adult Male Cardiopulmonary Bypass Neutrophils Myocardial Reperfusion Injury Middle Aged Enzyme Activation Myocarditis Heart Arrest Induced Humans L-Selectin Aged Peroxidase Protein C
Zdroj:	American journal of hematology. 67(3)
ISSN:	0361-8609
Popis:	To assess possible interactions between inflammation and activation of the anticoagulant protein C system during post-ischemic reperfusion protein C, APC, neutrophil L-selectin expression and myocardial myeloperoxidase activity (MPO) were measured in 19 patients undergoing cardiopulmonary bypass. After reperfusion for 10 min, APC to protein C ratio (APC/PC) increased from pre-reperfusion value 1.43 +/- 0.12 (mean +/- SEM) to 2.25 +/- 0.29, p = 0.015. Negative correlations were observed between APC/PC and MPO activity (Spearman r -0.64, p = 0.007) and APC/PC and neutrophil L-selectin expression (r = -0.7, p = 0.007, demonstrating that post-ishemic protein C activation was associated with decreased neutrophil tissue sequestration. Thus, physiological protein C activation may be involved in regulation of the inflammatory injury during reperfusion of human ischemic coronary circulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::43101bd7eaa5a184ff5072ee31655426 https://pubmed.ncbi.nlm.nih.gov/11391722 Zobrazit plný text záznamu Plný text