Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease
| Autor: | Kurcova, Sandra, Bardon, Jan, Vastik, Miroslav, Vecerkova, Marketa, Frolova, Monika, Hvizdosova, Lenka, Nevrly, Martin, Mensikova, Katerina, Otruba, Pavel, Krahulik, David, Kurca, Egon, Sivak, Stefan, Zapletalova, Jana, Kanovsky, Petr |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male subthalamic nucleus Time Factors Deep Brain Stimulation Observational Study Parkinson Disease Middle Aged Motor Activity nonmotor symptoms nervous system diseases surgical procedures operative Treatment Outcome nervous system Humans Female Prospective Studies therapeutics Research Article Aged Follow-Up Studies |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains. Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up. This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms. Patients at month 1 after STN-DBS had significantly reduced the Parkinson's disease Questionnaire scores (P = .018) and Scales for Outcomes in Parkinson's disease – Autonomic scores (P = .002); these scores had increased at Month 4 after DBS-STN. Nonmotor Symptoms Scale for Parkinson's Disease had improved significantly at Month 1 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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