Correlates of steady-state haematocrit and hepatosplenomegaly in children with sickle cell disease in Western Nigeria
| Autor: | B J, Brown, O J, Fatunde, O, Sodeinde |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | West African journal of medicine. 31(2) |
| ISSN: | 0189-160X 2000-2009 |
| Popis: | Sickle cell disease is a common genetic disorder in Nigeria.To determine the steady state haematocrit, liver size and spleen size in children with sickle cell disease and the factors that influence them.This was a retrospective study of children with sickle cell disorders who attended the anaemia clinic of the Children's Outpatient Department, University College Hospital, Ibadan between the years 2000-2009. Relevant data extracted from their case notes included socio-demographic variables, haemoglobin phenotype, steady state haematocrit and liver and splenic sizes. Means were compared with t-test and correlation tested with Pearson correlation. Statistical significance was set at p0.05.A total of 415 (Male: female ratio 1.1:1) children were studied and 385 (92.8%) and 30 (7.2%) of the children were of haemoglobin (Hb) SS and Hb SC phenotypes respectively. Their ages ranged from 0.5-17 years with a mean (SD) of 7.3 (4.4) years. Mean (SD) steady state haematocrit for children with HbSC was 28.3 (4.5) % and significantly higher than 24.1 (3.7) % in HbSS. Mean steady state haematocrit was also higher in children from higher than lower socio-economic classes. There was a negative correlation of haematocrit with age, with hepatomegaly and splenomegaly. Steady state hepatomegaly occurred more frequently in HbSS than in HbSC.Haemoglobin phenotype, age and socio-economic status have some modifying influences on the steady-state features of sickle cell disease in Nigerian children. In addition, increasing liver and spleen sizes seem to be related to a decreasing haematocrit. |
| Databáze: | OpenAIRE |
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