Thymocyte deletion can bias regulatory T cell formation toward low abundance self-peptide
| Autor: | Picca, Cristina Cozzo, Oh, Soyoung, Panarey, Laura, Aitken, Malinda, Basehoar, Alissa, Caton., Andrew J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
CD4-Positive T-Lymphocytes
Mice Inbred BALB C Reverse Transcriptase Polymerase Chain Reaction Interleukin-2 Receptor alpha Subunit Receptors Antigen T-Cell food and beverages Clonal Deletion hemic and immune systems chemical and pharmacologic phenomena Forkhead Transcription Factors Hemagglutinin Glycoproteins Influenza Virus Mice Transgenic Thymus Gland Flow Cytometry Lymphocyte Activation T-Lymphocytes Regulatory Article Mice Animals Peptides Cells Cultured |
| Popis: | Autoreactive CD4+ T cells can undergo deletion and/or become CD25+Foxp3+ Treg cells as they develop intrathymically, but how these alternative developmental fates are specified based on interactions with self-peptide(s) is not understood. We show here that thymocytes expressing an autoreactive TCR can be subjected to varying degrees of deletion that correlate with the amount of self-peptide. Strikingly, among thymocytes that evade deletion, similar proportions acquire Foxp3 expression. These findings provide evidence that Foxp3+ Treg cells can develop among members of a cohort of autoreactive thymocytes that have evaded deletion by a self-peptide, and that deletion and Treg cell formation can act together to bias the Treg cell repertoire toward low abundance self-peptide(s). |
| Databáze: | OpenAIRE |
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