A Multidimensional Cross-Sectional Analysis of Coronavirus Disease 2019 Seroprevalence Among a Police Officer Cohort: The PoliCOV-19 Study

Autor: Sendi, Parham, Baldan, Rossella, Thierstein, Marc, Widmer, Nadja, Gowland, Peter, Gahl, Brigitta, Büchi, Annina Elisabeth, Güntensperger, Dominik, Wider, Manon, Blum, Manuel Raphael, Tinguely, Caroline, Maillat, Cédric, Theel, Elitza S, Berbari, Elie, Dijkman, Ronald, Niederhauser, Christoph
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Open Forum Infectious Diseases
ISSN: 2328-8957
Popis: Background Protests and police fieldwork provide a high-exposure environment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. In this cross-sectional analysis, we investigated the seroprevalence among a police cohort, and sociodemographic, work, and health-related factors associated with seropositivity. Methods Study participants were invited for serological testing of SARS-CoV-2 and to complete online questionnaires. Serum neutralization titers toward the wild-type SARS-CoV-2 spike protein (expressing D614G) and the Alpha and Beta variants were measured in seropositive study participants. Results A total of 978 police personnel representing 35% of the entire staff participated from February to March 2021. The seroprevalence was 12.9%. It varied by geographic region, ranged from 9% to 13.5% in 3 regions, including the city; and was 22% in Bernese Seeland/Jura with higher odds for seropositivity (odds ratio [OR], 2.38 [95% confidence interval {CI}, 1.28–4.44], P=.006). Job roles with mainly office activity were associated with a lower risk of seropositivity (OR, 0.33 [95% CI, .14–.77], P=.010). Self-reported compliance with mask wearing during working hours was 100%; 45% of seropositive vs 5% of seronegative participants (P
The seroprevalence of anti–SARS-CoV-2 antibodies of police officers was comparable to that reported in the general population. The level of serum antibody titers correlates well with neutralization capacity. Low antibody titers acquired from natural infection are not effective against variants.
Databáze: OpenAIRE
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