Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP
| Autor: | Naoki, Kurata, Natsumi, Tokashiki, Keijo, Fukushima, Takaya, Misao, Nanae, Hasuoka, Kana, Kitagawa, Masato, Mashimo, John W, Regan, Toshihiko, Murayama, Hiromichi, Fujino |
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| Rok vydání: | 2019 |
| Předmět: |
Monocarboxylic Acid Transporters
Sialoglycoproteins Acetylation Peptide Fragments Gene Expression Regulation Neoplastic Histones Butyrates Cyclooxygenase 2 Cell Line Tumor Enzyme Induction Colonic Neoplasms Cyclic AMP Animals Humans E1A-Associated p300 Protein Receptors Prostaglandin E EP4 Subtype Cell Proliferation Histone Acetyltransferases |
| Zdroj: | European journal of pharmacology. 853 |
| ISSN: | 1879-0712 |
| Popis: | Microbiota produce short chain fatty acids (SCFAs), which are known to maintain gut homeostasis, by the fermentation of dietary fiber in the human colon. Among SCFAs, butyrate has been considered as the most physiologically effective SCFA in colorectal epithelial cells for growth and differentiation. Here we show that the E-type prostanoid 4 (EP |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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