The role of C-Fos in growth factor regulation of stromelysin/transin gene expression
| Autor: | L D, Kerr, B E, Magun, L M, Matrisian |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Platelet-Derived Growth Factor
Mice Inbred BALB C Binding Sites Base Sequence Epidermal Growth Factor Proto-Oncogene Proteins c-jun Recombinant Fusion Proteins Molecular Sequence Data Metalloendopeptidases 3T3 Cells Regulatory Sequences Nucleic Acid Rats Mice Transforming Growth Factor beta Enzyme Induction Animals Humans Tetradecanoylphorbol Acetate Matrix Metalloproteinase 3 Promoter Regions Genetic Proto-Oncogene Proteins c-fos Cells Cultured Protein Kinase C HeLa Cells Signal Transduction |
| Zdroj: | Matrix (Stuttgart, Germany). Supplement. 1 |
| ISSN: | 0940-1199 |
| Popis: | Expression of the rat stromelysin (transin) gene is stimulated by growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), and inhibited by transforming growth factor-beta (TGF beta). Stimulation by both EGF and PDGF requires the presence of factors that recognize the AP-1 binding site in the stromelysin promoter, but PDGF stimulation requires induction of the protooncogene c-fos, while EGF acts through a FOS-independent pathway. The FOS-independent pathway appears to involve protein kinase C (PKC), since EGF, but not PDGF, requires activated protein kinase C to stimulate stromelysin expression. TGF beta inhibition of stromelysin gene expression requires an upstream sequence, referred to as the TGF beta inhibitory element (TIE). FOS is also a part of a protein complex that binds to the TIE. The protooncogene FOS is therefore involved in both stimulation and inhibition of stromelysin gene expression. |
| Databáze: | OpenAIRE |
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