| Autor: |
L Iu, Skliarov, I N, Sbitneva, N A, Kopina, I G, Sidorovich |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Bioorganicheskaia khimiia. 26(4) |
| ISSN: |
0132-3423 |
| Popis: |
Pyridoxyl residue was suggested to be used as a multifunctional protective and modifying group in peptide synthesis. The modification was carried out by introducing the pyridoxyl residue in free or partially protected peptides or by the addition of amino acid pyridoxyl esters by the methods of conventional peptide synthesis without the removal of the pyridoxyl group at the terminal stages of the synthesis (the second approach is more convenient). Pyridoxyl residue was also used as a spacer in solid phase peptide synthesis. It was attached to the polymer by the alkylation of the hydroxyl groups or of the pyridine ring of the pyridoxyl derivatives with the chloromethylated styrene-divinylbenzene copolymer (the standard Merrifield resin). Potentials for the use of pyridoxyl derivatives in the synthesis of linear, multiplet, and cyclic peptides are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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