| Autor: |
Raquel, Rodríguez-Guzmán, Mohamed M, Radwan, Charles L, Burandt, John S, Williamson, Samir A, Ross |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Natural product communications. 5(9) |
| ISSN: |
1934-578X |
| Popis: |
Phytochemical evaluation of Zanthoxylum monophyllum has led to the isolation of the alkaloid 4-methoxy-N-methyl-2-quinolone (1) with a significant activity against methicillin-resistant Staphylococcus aureus (MRSA), with an IC50 value of 1.5 microg/mL. Xenobiotic biotransformation of 1 has been conducted with the general goal of increasing the bioactivity of the compound and contributing new leads for further pharmacological research. Twenty-nine microorganisms were used for screening and two (Aspergillus flavus and Cunninghamella echinulata var. echinulata) were able to transform compound 1 to 4-methoxy-2-quinolone (2). Structural identification of the compounds was based on NMR, IR, and MS data. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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