Natural killer (NK) cell receptors' repertoire in couples with recurrent spontaneous abortions
| Autor: | Marighoula, Varla-Leftherioti, Maria, Spyropoulou-Vlachou, Demetra, Niokou, Theodora, Keramitsoglou, Areti, Darlamitsou, Christina, Tsekoura, Miltiadis, Papadimitropoulos, Virginia, Lepage, Christos, Balafoutas, Catherine, Stavropoulos-Giokas |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Abortion Habitual Family Characteristics Genotype Histocompatibility Antigens Class I Polymerase Chain Reaction Trophoblasts Killer Cells Natural Receptors KIR Antigens CD HLA Antigens Pregnancy Receptors KIR2DL1 Humans Receptors Natural Killer Cell Female Lectins C-Type Receptors Immunologic NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D |
| Zdroj: | American journal of reproductive immunology (New York, N.Y. : 1989). 49(3) |
| ISSN: | 1046-7408 |
| Popis: | Natural killer (NK) cell receptors (NKRs) have been suggested to protect trophoblast, but their function at the fetomaternal interface remains unknown. To investigate if the outcome of pregnancy depends on women's NKRs, we studied the NKR repertoire in couples with recurrent spontaneous abortions (RSA).Twenty-six childless couples withor = 2 abortions, characterized by alloimmune abnormalities, and 26 control couples were genotyped for five killer immunoglobulin-like receptors (KIR) and two CD94/NKG receptors, known to have as ligands human leukocyte antigen (HLA) class I molecules with trophoblastic expression: inhibitory 2DL1,2,3 and activating 2DS1,4 KIRs, inhibitory NKG2A and activating NKG2C. Detected repertoires of women and partners were compared between the two groups.Less aborters than controls were found to have all three inhibitory KIRs (30.77% versus 69.23%, P = 0.01), some of them had only one inhibitory KIR (19.23% versus 3.85%, P = 0.08) and most of them were lacking inhibitory KIRs possessed by their husbands (57.69% versus 15.38%, P = 0.001).Women with alloimmune abortions have a limited inhibiting KIR repertoire and such miscarriages may occur because trophoblastic HLA class I molecules are recognized by decidual NK cells lacking the appropriate inhibitory KIRs. |
| Databáze: | OpenAIRE |
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