Predictive Value of Hematological Inflammatory Markers in Endometrial Neoplasia
| Autor: | Besim Haluk, Bacanakgil, Isik, Kaban, Fehmi, Unal, Rabia, Guven, Ece, Sahin, Sezgi Gullu, Yildirim |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Aged 80 and over Blood Platelets Neutrophils platelet lymphocyte ratio Middle Aged Prognosis endometrial hyperplasia-neutrophil lymphocyte ratio Endometrial Neoplasms ROC Curve Endometrial cancer Case-Control Studies Endometrial Hyperplasia Biomarkers Tumor Humans Female Lymphocytes Inflammation Mediators Aged Follow-Up Studies Retrospective Studies Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Objective: To investigate the predictive role of neutrophil lymphocyte ratio (NLR) and the platelet lymphocyte ratio (PLR) as hematological inflammatory markers in cases of endometrial hyperplasia and cancer. Material and Method: This retrospective study was performed between 2005-2015 with 247 cases of 83 endometrial adenocarcinoma (group 1), 64 of endometrial hyperplasia (group 2) and 100 controls (group 3) who underwent a curettage due to abnormal uterine bleeding and had a normal histopathology in our tertiary clinic. The cases were chosen from patients without chronic diseases, that do not have infection or medication that could affect the systemic inflammatory response. Pre-intervention blood parameters were taken into account. The neutrophil/ lymphocyte and platelet/lymphocyte ratios were and statistical comparisons of the groups were conducted. Results: The age distribution of 247 patients was between 26 and 85 years, and the mean age was 48.8 ± 8.92.The median age was 54 in group 1, 46 in group 2 and 45 in group 3. The age was significant between group 1 and the other groups (p=0.001). Some 71% of the cases were premenopausal and 29% were postmenopausal, the latter being significantly more frequent in group 1 (62.7%; p=0.001). Of the cases with endometrial hyperplasia, 42 (65.6%) had simple and 22 (34.4%) have atypical-complex lesions. The median NLRs in groups 1, 2, and 3 were 2.15, 2.10, and 1.92, respectively, with median PLRs of 135.1, 134.0 and 145.6. There was a statistically significant difference between the NLR measurements of the cases from different groups (p=0.048; p |
| Databáze: | OpenAIRE |
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